Obesity-related hypertension and chronic kidney disease: from evaluation to management

• DOI: 10.23876/j.krcp.23.072
• Publication Date: 2023-07-28T06:17:54Z
• Authors: Mi-Hyang Jung; Sang-Hyun Ihm
• Keywords: Management of obesity; Pathophysiology of hypertension

With the recent obesity pandemic, obesity-related hypertension and its complications (e.g., heart failure, coronary disease, chronic kidney disease [CKD]) are gaining attention in clinical research fields. Obesity-related frequently precedes onset of CKD aggravates progression. In this review, we discuss role visceral fat pathophysiology potential therapeutic strategies for prevention management. Various factors, including sympathetic nervous system, renin-angiotensin-aldosterone inflammatory pathways, intricately involved pathogenesis hypertension. These factors individually jointly contribute to development (usually sodium-sensitive or resistant hypertension) and, ultimately, progression CKD. From a standpoint, decline renal function advanced further makes blood pressure control challenging since only few options available pressure-lowering medications. Proactive lifestyle modification, pharmacological treatment obesity, bariatric surgery can be considered Furthermore, intensive is required prevent halt