Correlation between Neutrophil/Lymphocyte Ratio (NLR), lipid profile, lesion location and vascular cognitive impairment in acute ischemic stroke patients

• DOI: 10.24198/jkp.v12i2.2526
• Publication Date: 2024-08-23T07:06:29Z
• Authors: Ira Ristinawati; Kenneth Tan; Benedictus Benedi...; Muhammad Hafizhan; Stefanus Erdana P...; Suroto Suroto; Diah Kurnia Mirawati; Subandi Subandi; Rivan Danuaji; Pepi Budianto; Yetty Hambarsari; Baarid Luqman Hamidi; Hanindia Riani Pr...; Ervina Arta Jayan...; Teddy Tejomukti; Raden Andi Ario T...
• Keywords: Montreal Cognitive Assessment; Stroke; Lipid Profile; Hyperlipidemia

Background: Stroke is the leading cause of long-term disability with significant clinical and socioeconomic impact worldwide. Hyperlipidemia inflammation play major roles in ischemic stroke. This research focuses on correlation three factors, namely Neutrophil-Lymphocyte Ratio (NLR), lipid profile, lesion location, Vascular Cognitive Impairment (VCI). These factors may serve as potential predictors for VCI. Purpose: aims to study between NLR, location vascular cognitive impairment. Besides, this explore those biomarkers Methods: was a cross-sectional which included 107 patients diagnosed stroke from February 2022 January 2023 history admission hospital within 72 hours. After signed an informed consent form, every patient had taking, physical exam, routine blood test, Mini Mental State Examination (MMSE) Montreal Assessment Indonesian Version (MoCA-Ina) first day. Statistical tests were done Spearman method. Results: The data distribution not normal INR MoCA-INA values (p<0.05). Total cholesterol insignificantly (p=0.092) correlated score low value (r=-0.293). HDL significantly (p=0.035) moderate (r=0.461). LDL (p=0.028) (r=-0.387). Triglycerides (p=0.440) very weak (r=-0.137). NLR (p=0.015) (r=-0.412). Conclusions: Lipid profile impairment post patients, being protective factor, risk factor. associated worse function directly proportional NLR. Lesion reporting highly heterogeneous more uniformed recommended future research.