A 1.1 Mb duplication CNV on chromosome 17 contributes to skeletal muscle development in Boer goats

• DOI: 10.24272/j.issn.2095-8137.2022.384
• Publication Date: 2023-02-07T02:26:33Z
• Authors: Ying Yuan; ; ; Wei-Yi Zhang; Bai-Gao Yang; Dong-Ke Zhou; Lu Xu; Yong-Meng He; Hao-Yuan Zhang; Cheng-Li Liu; Yue-Hui Ma; Ming-Xing Chu; Wen-Guang Zhang; Hui-Jiang Gao; Lin Jiang; Fu-Ping Zhao; Lu-Pei Zhang; Ri-Su Na; Baatarchogt Oyung...; Yan-Guo Han; Yan Zeng; Shi-Zhi Wang; Huai-Zhi Jiang; Hong-Ping Zhang; Xun-Ping Jiang; Jian-Ning He; Hao Liang; Kaushalendra Kaus...; Ya-Wang Sun; Yong-Fu Huang; Yong-Ju Zhao; Zhong-Quan Zhao; Guang-Xin E
• Keywords: Boer goat

The Boer goat is one of the top meat breeds in modern animal husbandry and has attracted widespread attention for its unique growth performance. However, genetic basis muscle development remains obscure. In this study, we identified specific structural variants based on genome-wide selection signals analyzed molecular heredity related candidate genes development. A total 9 959 autosomal copy number variations (CNVs) were through signal analysis 127 genomes. Specifically, confirmed that highest CNV (HSV) was a chromosomal arrangement containing an approximately 1.11 Mb (CHIR17: 60062304–61171840 bp) duplicated fragment inserted reverse orientation 5 362 bp deleted region (CHIR17:60145940–60151302 with overlapping (e.g., <i>ARHGAP10</i>, <i>NR3C2</i>, <i>EDNRA</i>, <i>PRMT9</i>, <i>TMEM184C</i>). homozygous HSV genotype (+/+) found 96% goats but not detected Eurasian only 4% indigenous African goats. expression network three (<i>ARHGAP10</i>, <i>EDNRA</i>) regulating dose transcription constructed by RNA sequencing. Results indicated these involved proliferation differentiation skeletal satellite cells (SMSCs) their overexpression significantly increased <i>SAA3</i>. contributed to superior via effects genes.