Effects of gradient high-field static magnetic fields on diabetic mice

• DOI: 10.24272/j.issn.2095-8137.2022.460
• Publication Date: 2023-01-13T00:36:19Z
• Authors: Biao Yu; ; ; Chao Song; Chuan-Lin Feng; Jing Zhang; Ying Wang; Yi-Ming Zhu; Lei Zhang; Xin-Miao Ji; Xiao-Fei Tian; Guo-Feng Cheng; Wei-Li Chen; Vitalii Zablotskii; Hua Wang; Xin Zhang
• Keywords: Malondialdehyde

Although 9.4 T magnetic resonance imaging (MRI) has been tested in healthy volunteers, its safety diabetic patients is unclear. Furthermore, the effects of high static fields (SMFs), especially gradient vs. uniform fields, have not investigated diabetics. Here, we consequences exposure to 1.0–9.4 SMFs different gradients (&gt;10 T/m 0–10 T/m) on type 1 (T1D) and 2 (T2D) mice. We found that 14 h prolonged treatment (as as 55.5 (1.0–8.6 T) had negative T1D T2D mice, including spleen, hepatic, renal tissue impairment elevated glycosylated serum protein, blood glucose, inflammation, anxiety, while quasi-uniform at did induce same effects. In regular mice (blood glucose ≥16.7 mM), &gt;10 increased malondialdehyde (<i>P&lt;</i>0.01) decreased superoxide dismutase (<i>P&lt;</i>0.05). However, severe ≥30.0 significantly damage reduced survival rate. <i>In vitro</i> cellular studies showed reactive oxygen species apoptosis MS-1 cell number proliferation. Therefore, this study high-field (35–1 380 times higher than current clinical MRI) can with T1D, whereas produce effects, providing important information for future development application SMFs, MRI.