Alterations in bovine neutrophil function during the periparturient period

• DOI: 10.2460/ajvr.1989.50.02.207
• Publication Date: 2025-02-06T20:42:58Z
• Authors: Marcus E. Kehrli; Brian J. Nonnecke; James A. Roth
• Keywords: Labor, Obstetric; Time Factors; Epidemiology; Neutrophils; Postpartum Period; Antibody-Dependent Cell Cytotoxicity; 630; Veterinary Pathology and Pathobiology; Mammary Glands, Animal; Large or Food Animal and Equine Medicine; Veterinary Microbiology and Immunobiology; Phagocytosis; Cell Movement; Pregnancy; Superoxides; Luminescent Measurements; Escherichia coli; Animals; Pregnancy, Animal; Cattle; Female; and Public Health; Veterinary Preventive Medicine; Iodine

SUMMARY Neutrophils from 8 Holstein heifers were evaluated for function during the periparturient period. Random migration ingestion of bacteria, superoxide anion production, native (nonenhanced) chemiluminescence, iodination, and antibody-dependent, cell-mediated cytotoxicity by neutrophils determined. Foremilk samples bacteria. Significant ( P < 0.05) increases in random neutrophils, chemiluminescence evident 2 weeks before parturition then decreased dramatically first week after parturition. These impairments neutrophil may be manifested as a severe cumulative deficit defenses afforded neutrophil.