Pharmacokinetics of flunixin meglumine in lactating cattle after single and multiple intramuscular and intravenous administrations

• DOI: 10.2460/ajvr.1990.51.09.1464
• Publication Date: 2024-01-24T16:13:51Z
• Authors: K. L. Anderson; C. A. Neff-Davis; L. E. Davis; V. D. Bass
• Keywords: Intramuscular injection

SUMMARY The pharmacokinetics of flunixin were studied in 6 adult lactating cattle after administration single iv and im doses at 1.1 mg/kg body weight. A crossover design was used, with route first each cow determined randomly. Plasma milk concentrations total by use high-pressure liquid chromatography, using an assay a lower limit detection 50 ng flunixin/ml. best described 2-compartment, open model. After administration, mean plasma rapidly decreased from initial > 10 μg/ml to nondetectable 12 hours administration. distribution phase short (t ½α , harmonic = 0.16 hours) the elimination more prolonged ½β 3.14 hours). Mean ± sd clearance 2.51 0.96 ml/kg/min. for ) 5.20 hours. Bioavailability dosing gave (n 5) 76.0 28.0%. Adult, cows 6) challenge inoculated endotoxin as model acute coliform mastitis. multiple (total 7 doses; remainder 8-hour intervals, approximately 1 2 0.5 just prior dosing. Flunixin not detected any sampling during study. necessary induce therapeutic effects are unknown. Results our study indicate that meglumine intervals would produce similar those demonstrated be effective clinically treatment equine musculoskeletal disorders colic.