Evaluation of outcome and prognostic factors for dogs living greater than one year after diagnosis of osteosarcoma: 90 cases (1997–2008)

• DOI: 10.2460/javma.245.10.1141
• Publication Date: 2014-10-30T14:21:57Z
• Authors: William T. N. Culp; Francisco Olea-Po...; Jennifer Sefton; Charles F. Aldridge; Stephen J. Withrow; Mary H. Lafferty; Robert B. Rebhun; Michael S. Kent; Nicole Ehrhart
• Keywords: Univariate analysis; Medical record

To evaluate clinical characteristics, outcome, and prognostic variables in a cohort of dogs surviving > 1 year after an initial diagnosis osteosarcoma.Retrospective case series.90 client-owned dogs.Medical records for 11-year period from 1997 through 2008 were reviewed, patients with appendicular osteosarcoma that lived histopathologic studied. Variables including signalment, weight, serum alkaline phosphatase activity, tumor location, surgery, adjuvant therapies recorded. Median survival times calculated by means Kaplan-Meier function. Univariate analysis was conducted to compare the function categorical variables, Cox proportional hazard model used likelihood death on basis selected risk factors.90 met inclusion criteria; laboratory information not available all cases. age 8.2 years (range, 2.7 13.3 years), median weight 38 kg (83.6 lb; range, 21 80 [46.2 176 lb]). Serum activity high 29 60 (48%) dogs. The most common location distal portion radius (54/90 [60%]). Eighty-nine 90 (99%) underwent 78 (87%) received chemotherapy. Overall, 49 (54%) developed metastatic disease. time beyond 243 days 1,899 days). Dogs surgical-site infection limb-sparing surgery had significantly improved prognosis diagnosis, compared did develop infections.Results present study indicated approximately 8 months. As reported previously, development undergoing affected warrants further study.