Treatment of a patient with severe haemophilia A presenting with left extra pleural haematoma and diagnosed with inhibitors – case report

• DOI: 10.2478/jhp-2022-0010
• Publication Date: 2022-05-20T22:21:52Z
• Authors: Arijit Das; Anupam Dutta; Ramanan BBV; Sanchu TK Sreeraj
• Keywords: Clotting factor; Haemophilia B; Prothrombin complex concentrate

Abstract Haemophilia is an inherited X-linked bleeding disorder characterised by a deficiency or absence of clotting factor VIII (haemophilia A) IX B), which can cause musculoskeletal bleeding. The standard treatment for haemophilia with concentrates to replace the missing deficient factor. However, there risk that immune system develops antibodies against exogenous factor, known as inhibitors. Managing patients and inhibitors who develop in unusual sites be challenging treating physician. Here, we present rare case patient severe A was diagnosed after developing left posterior chest wall (extra pleural haematoma). successfully managed activated prothrombin complex concentrate (aPCC) (FEIBA: FVIII inhibitor bypassing activity; Baxter AG), pain swelling gradually resolved over three weeks. This emphasises importance clinical suspicion formation already presenting does not respond treatment.