The activity of monocyte-derived macrophages after stimulation with platelet-rich and platelet-poor concentrates. Study on an ovine model of insertion of a tibial implant coated with silicon-doped diamond-like carbon

• DOI: 10.2478/jvetres-2024-0003
• Publication Date: 2024-01-30T16:44:09Z
• Authors: Bartłomiej Szymczak; Andrzej Junkuszew; Krzysztof Patkowski; Tomasz Szponder; Dominika Nguyen Ngoc; Beata Drzewiecka; Aleksandra Sobczy...; Joanna Wessely-Sz...
• Keywords: Monocyte

Macrophages are crucial immune cells that play a role in tissue repair and can exhibit pro- or anti-inflammatory behaviour based on environmental stimulation. Their functional phenotype be affected by platelet-derived products as determined those products' composition. When the inflammatory response caused implantation is excessive, it lead to rejection of implant. Therefore, thorough evaluation implant haemocompatibility necessary minimise undesirable consequences.