Synthesis, spectroscopic characterization, crystal structure and antifungal activity of thiourea derivatives containing a thiazole moiety

• DOI: 10.2478/s11532-010-0014-2
• Publication Date: 2010-03-16T16:03:19Z
• Authors: Sohail Saeed; Naghmana Rashid; Peter Jones; Rizwan Hussain; Moazzam Bhatti
• Keywords: Moiety; Monoclinic crystal system; Thiazole; Proton NMR

Abstract Four novel thiourea derivatives containing a thiazole moiety were synthesized and characterized by IR, 1H 13C NMR, mass spectrometry elemental analysis. The crystal structure of 1a was determined from single X-ray diffraction data. It crystallizes in monoclinic space group P21/n with unit cell dimensions = 11.7752(6) Å, b= 3.8677(2) c= 27.4126(13) Å β 92.734(5) Å. There is strong intramolecular hydrogen bond the type N-H⋯O, H⋯O distance 2.5869(19) fragmentation pattern has also been discussed. antifungal activity compounds studied broth micro-dilution method poisoned food technique. 1b 1c possessed broad spectrum activity.