The Role of Tumor Microenvironment and Impact of Cancer Stem Cells on Breast Cancer Progression and Growth

• DOI: 10.2478/sjecr-2018-0018
• Publication Date: 2019-01-10T09:03:10Z
• Authors: Nenad Markovic; Ana Lukovic; Nebojsa Arsenijevic; Srdjan Ninkovic; Biljana Ljujic
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Abstract Breast cancer is not only a mass of genetically abnormal tissue in the breast. This well-organized system complex heterogeneous tissue. Cancer cells produce regulatory signals that stimulate stromal to proliferate and migrate; then, elements respond these by releasing components necessary for tumor development provide structural support, vasculature, extracellular matrices. Developing tumors can mobilize variety cell types from both local distant niches via secret chemical factors derived themselves or neighboring disrupted growing neo-plasm, such as fibroblasts, immune inflammatory cells, endothelial cells. CSCs are group very few tumorigenic (able form tumors) defined those within selfrenew lead tumorigenesis. BCSCs represent small population have stem characteristics related breast cancer. There different theories about origin BCSCs. responsible carcinoma metastasis. Usually, there metastatic spread bones, rarely lungs liver. A phenomenon allows make transition epithelial mesenchymal expression thus avoid effect cyto toxic agents epithelial-mesenchymal (EMT). During this process, change their molecular terms loss taking phenotype. process plays key role progression, invasion, metastasis tumors.