Analogs of biologically active compounds IX. Synthesis of several new uracil and pteridine 6-aza-analogs based on cyclization of arylhydrazones derived from mesoxalic acid

• DOI: 10.24820/ark.5550190.p010.123
• Publication Date: 2017-11-14T20:25:30Z
• Authors: David Novosád; Jakub Stýskala
• Keywords: Pteridine; Uracil

A series of 5C and 5N substituted 3-oxo-2-phenyl-1,2,4-triazine-6-carbonitriles 8-imino-2-arylpyrimido[4,5e][1,2,4]triazine-3,6(2H,5H)-diones (6-aryl-6-azapteridines) are described via a cyclocondensation reaction from the corresponding aryliminohydrazones with CDI.The required were obtained starting compound -malononitrile.These prepared compounds tested for cytotoxic activity on cancer cell lines.