Effect of Intravenous Polyunsaturated Fatty Acids Administration on Gastric Mucosal Integrity in Pig-tailed Macaques with Obstructive Jaundice

• DOI: 10.24871/12120118-14
• Publication Date: 2011-01-04
• Authors: Dadang Makmun; Dondin Sajuthi; Daldiyono Daldiyono; Adi Winarto; Erni Sulistiawati

Background: Acute gastric mucosal injury commonly occurs in patients with obstructive jaundice. We studied the effect of intravenous polyunsaturated fatty acids (PUFA) administration on integrity pig-tailed macaques (Macaca nemestrina) jaundice by ligating common bile duct (CBD). Method: The study was conducted between February 2009 and May 2010 at Primate Research Center, Bogor Agricultural Institute. Eight selected male 6.625 ± 0.83 kg body weight were used divided into two groups. In both groups, laboratory examination, including liver function tests upper gastrointestinal endoscopy performed before CBD ligation every weeks after ligation. first group, PUFA dose 2 g/day administered day since four post-ligation up to later, second eight later. Results: increased total bilirubin, direct indirect aspartate aminotransferase, alanine alkaline phosphatase gamma glutamyl transpeptidase obviously found, meanwhile decreased albumin level detected cholinesterase groups remained unchanged. Ulcer formation occurred among group during 4 ligation, these ulcers showed obvious healing within administration. there no significant ulcer Conclusion: potential appearance acute which reflected significantly also have successfully developed animal model based result tests. Keywords : injury, administration, jaundice, pig- tailed