Effect of COVID-19 on hereditary angioedema activity and quality of life

• DOI: 10.2500/aap.2021.42.210066
• Publication Date: 2021-09-06T16:52:36Z
• Authors: Ozge Can Bostan; Gulseren Tuncay; Ebru Damadoglu; Gul Karakaya; Ali Fuat Kalyoncu
• Keywords: Hereditary Angioedema; 2019-20 coronavirus outbreak; Coronavirus Infections

Background: The demonstration that severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) enters the cell via angiotensin-converting enzyme receptor has raised concerns that, in hereditary angioedema (HAE), a disease characterized by bradykinin-mediated attacks, 2019 (COVID-19) may trigger increase frequency and/or severity of or cause more symptoms COVID-19. Objective: objective was to evaluate COVID-19 patients with HAE, course HAE activity, and quality-of-life scores during pandemic. Methods: Patients diagnosed for at least 6 months were included study. 7-day Angioedema Activity Score Quality Life (AE-QoL) Questionnaire first completed onset pandemic between March 12 June 1, 2020, then SARS-CoV-2 infection, third month after recovering from Results: Ten 67 (14.9%) median (interquartile range) age 10 35.5 years (28.0-55.0 years). Six (60%) women. During COVID-19, five (50%) had no attack. Two experienced significant activity compared their basal scores. remaining three similar lower attack than level. Four (40%) relative attacks convalescence period. There statistically difference among pre-COVID-19, post-COVID-19 periods function, mood, fear shame, nutrition, total AE-QoL although dimension relatively affected (p = 0.06). Conclusion: Although sample size small, analysis our data supported not HAE. Also, there scores, frequency,