Clinical characteristics of patients with obesity associated with bronchial asthma, depending on the age of onset

• DOI: 10.25040/lkv2023.03-04.037
• Publication Date: 2024-01-30T09:09:57Z
• Authors: V. Kachkovska
• Keywords: Atopy

Introduction. Previous studies have identified two primary phenotypes of bronchial asthma (BA) associated with obesity: early atopic and late without atopy. These differ in age onset, pathogenic mechanisms development, response to basic treatment. The aim present study was analyze clinical anamnestic data patients BA accompanied obesity, focusing on the onset. Material methods. A cohort 195 obesity were examined. obtained results compared database similar indeces a control group consisted 95 healthy individuals allergies or atopy symptoms their histories. All participating signed an informed consent agreement. subdivided into groups based onset age. Group I included 100 early-onset (early phenotype), while II comprised late-onsetB (late phenotype). Analysis showed that there no significant differences gender between (p more than 0.05). diagnosis severity course established according recommendations GINA-2016 its subsequent versions. ACQ-5 questionnaire used assess control. AQLQ quality life patients. approved by Bioethics Commission Educational Scientific Medical Institute Sumy State University. Statistical analysis carried out using SPSS-17 program. results. No 0.05) detected age, sex, burdened heredity, bone/muscle regarding disease. However, had longer disease duration late-onset is equal 0.001). It also revealed certain correlation flare-ups seasonal non-specific triggers depending Namely, experienced exacerbation twice as often during flowering period plants, those Among BA, 90.5% late-stage frequent exacerbations cold season early-stage BA. This difference statistically 0.001) frequency being 1.7 times higher. Additionally, physical activity triggered every second patient same observed third 0.009). attacks requiring use salbutamol 2.4 observation higher needs administration daytime What concerns complaints examination data, it incidence shortness breath, general weakness, fatigue both patients, productive cough likely occur indices control, measured questionnaire, pulmonary function However reversibility obstruction lower Conclusions. Based accomplished functional In particular, duration, experience due plant flowering, exhibit morning exacerbations, require intense systemic glucocorticoids administration. Distinctive features occupational hazards, acute respiratory viral infections, exertion, combination above factors oftenly caused exacerbation. Daytime need take salbutamol, (including sputum), obstruction, characteristic for