Duloxetine-Induced Manic Switch in a Patient with Bodily Distress Disorder: A Case Report and Brief Literature Review

• DOI: 10.25259/bjpsy_8_2024
• Publication Date: 2025-03-11T10:06:13Z
• Authors: Sukriti Mukherjee; Sukanto Sarkar

Duloxetine, a dual-action antidepressant, is widely used to treat depression, anxiety, and chronic pain. While it generally considered safe, rare cases of Duloxetine-induced manic switches have been reported. We present unique case woman with Bodily Distress Disorder who developed symptoms following Duloxetine therapy. Despite complex medical history extensive evaluations, no prior mood disorders were diagnosed. A family severe mental illness was the sole predictor bipolarity. The switch occurred after discontinuation Quetiapine, suggesting its protective role during initial therapy Duloxetine. Manic an infrequent adverse effect only isolated reports in literature, primarily at doses between 40–120 mg/day. review existing literature underscores rarity switches, new last 15 years, highlighting need for vigilance monitoring changes treatment, particularly patients potential bipolar predictors. This emphasizes importance comprehensive psychiatric assessment careful medication optimize treatment outcomes minimize risks.