Overdose of Dolutegravir in combination with tenofovir disaproxil fumarate/emtricitabine in suicide attempt in a 21-year old patient

• DOI: 10.26226/morressier.572768e5d462b8029237f2f3
• Publication Date: 2020-02-19T15:21:58Z
• Authors: Marcel Lee
• Keywords: Emtricitabine; Tenofovir; Dolutegravir

A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose his antiretroviral therapy (ART) comprising dolutegravir (DTG -Tivicay®) and tenofovir disaproxil fumarate/emtricitabine (Truvada®) suicidal intention.On admission, the did not show any clinical signs intoxication laboratory findings were unremarkable.After 6 hours intensive care monitoring, referred to a psychiatric clinic.5 days day intoxication, serum creatinine levels increased high normal values (1.2 mg/dl).However, never exceeded upper threshold.8 12 weeks later, normalized measured prior intoxication.No other adverse events occurred, does suffer from permanent impairments.