Defining sex differences in selected lipid metabolites of blood plasma in Wistar rats.

• DOI: 10.26402/jpp.2019.4.14
• Publication Date: 2019-08-01
• Authors: Andrea Leškaničová; Olga Chovancova; Marián Babinčák; Alžbeta Blichárová; Mariana Kolesárová; Denisa Maceková; Jozef Kostolný; B Smajda; Terézia Kisková
• Keywords: Sexual dimorphism; Sex characteristics; Lipid Profile

There is an increasing attention to the role that sex/gender plays in health, behavior and outcomes. Even though we know males females are not same, experiments have sometimes been carried out without considering sex scientific research. It essential for scientists clinicians consider differences as one of underlying physiological determinants health disease provide building blocks evidence-based, individualized medicine. Our work aimed reveal sex-associated lipid metabolite levels adult female (n = 10) male Wistar rats, aged 60 days. Partial least square determination analysis (PLS-DA) method a variance importance projection (VIP) score was used identify key sex-specific metabolites. results show all groups metabolites: lysophosphatidylcholines (lysoPCs), phosphatidylcholines (PCs), sphingomyelins (SMs) significant sex-dependent pattern. According our results, more than half lysoPCs studied showed features. PCs tend be significantly elevated blood plasma females. The most distinct increase 90% SMs has revealed plasma, compared with males. VIP score, important feature PC aa C38:4. study points dimorphism metabolism. identification main features may play preclinical clinical practice.