Subclinical atherosclerosis of the carotid arteries in patients with rheumatoid arthritis with low cardiovascular risk

• DOI: 10.26442/00403660.2023.05.202203
• Publication Date: 2023-07-16T20:39:55Z
• Authors: Elena V. Gerasimova; Tatiana V. Popkova; Maria V. Shalygina; Irina G. Kirillova; Daria A. Gerasimova; Svetlana I. Glukhova; Evgeny L. Nasonov
• Keywords: Subclinical infection

To evaluate the detection rate of subclinical carotid atherosclerosis in rheumatoid arthritis (RA) patients with low cardiovascular risk (CVR). The study included 182 RA CVR (mSCORE<1%) and no established diseases a control group comprising 100 people. Atherosclerotic lesion arteries was assessed using Doppler ultrasound determined by atherosclerotic plaque (ASP) - local increase thickness intima-media complex (IMT) >1.5 mm. Carotid ASP were observed more frequently than (17% versus 8%; p=0.02). frequency did not depend on disease's stage or activity ongoing therapy. In RA, associated traditional factors: detected 4 times often men women (48% 12%, p<0.01); IMT correlated age (R=0.46), body mass index (R=0.17), LDL-C level (R=0.20), systolic blood pressure (R=0.17); p<0.05 all cases. According to multivariate model, developing increased presence dyslipidemia (odds ratio OR 2.97; 95% confidence interval CI 1.36-6.49; p=0.006) arterial hypertension (OR 2.16; 1.03-4.54; p=0.04). ASP, sCD40L (R=0.32; p=0.04) cholesterol concentration (R=0.39; p=0.01). Subclinical lesions 24% almost 2 group. CVR, 2-3 concomitant dyslipidemia. factors age, gender, lipid levels indicators, cases an immunoinflammatory marker sCD40L.