Specific Composite Biomarker Profiles for β-Amyloid Accumulation in Peripheral Blood in Healthy Subjects Relevant to Biological Factors: Comparison with Patients with Dementia

• DOI: 10.26502/jbb.2642-91280125
• Publication Date: 2024-01-31T05:55:25Z
• Authors: Kouji Satoh; Maremi Sato-Ueshima; Hiroyo Kagami-Kat...; Masakazu Nakamura; Akihiko Ogata; Mari Maeda-Yamamoto; Jun Nishihira
• Keywords: Amyloid (mycology)

Measurement of amyloid concentration in blood using time-of-flight mass spectrometry was developed, and the combined normalized score precursor proteins (composite biomarker: CM) plasma found to be related accumulation β-amyloid (Aβ) brain.Therefore, we measured CM value healthy subjects aged 30-79 years investigated association between clinical characteristics multiple regression decision tree analyses.The results indicated that associated with age, sex, ApoE genotype, glucose, Mg subjects.Factors affecting values differed by age.The patients central nervous system disorders were higher than those subjects.Moreover, relationship concentrations subjects.These suggest can used as a biomarker for onset dementia, including Alzheimer's disease.The combination component may allow more accurate diagnosis.