Hierarchical dinucleotide distribution in genome along evolution and its effect on chromatin packing

• DOI: 10.26508/lsa.202101028
• Publication Date: 2021-06-24T16:10:18Z
• Authors: Zhicheng Cai; Yueying He; Sirui Liu; Yue Xue; Hui Quan; Ling Zhang; Yi Qin Gao
• Keywords: CpG site; Compartmentalization (fire protection); Differentially methylated regions

Dinucleotide densities and their distribution patterns vary significantly among species. Previous studies revealed that CpG is susceptible to methylation, enriched at topologically associating domain boundaries its along the genome correlates with chromatin compartmentalization. However, multi-scale organizations of in linear genome, role organization, how they change evolution are only partially understood. By comparing different genomic length scales, we quantify difference between distributions species evaluate hierarchical uneven appears evolution. The clustering based on consistent phylogenetic tree. Interestingly, found structure be correlated many especially for mammals avians, mosaic genomes these