Veratrilla baillonii Franch alleviate the symptoms of diabetes in type 2 diabetic rats induced by high-fat diet and streptozotocin

• DOI: 10.26599/fshw.2022.9250116
• Publication Date: 2023-06-07T06:28:54Z
• Authors: Chunlan Yan; Zhihao Zhang; Liqun Ma; Xinyi Xu; Muhammad Azhar; Xianju Huang; Jianxun Shi; Jun Li
• Keywords: veratrilla baillonii franch; type 2 diabetes mellitus; Nutrition. Foods and food supply; TX341-641; skeletal muscle; glut4; liver injury

Our previous research studies have shown that&nbsp;<em>Veratrilla baillonii</em>&nbsp;Franch (<em>V</em>. baillonii), a food supplement used by ethnic minorities in Southwest China, has&nbsp;multiple&nbsp;pharmacological activities,&nbsp;such as detoxification, anti-inflammatory, antioxidant, and anti-insulin resistance.&nbsp;However,&nbsp;the detailed signal pathways&nbsp;for&nbsp;its salutary&nbsp;effect on damages multiple organs due to type 2 diabetes mellitus (T2DM)&nbsp;remains&nbsp;unclear. The current study is evaluate&nbsp;the&nbsp;therapeutic effects of <em>V</em>. baillonii T2DM rats explore the underlying mechanisms. The&nbsp;T2DM rat model was successfully established high-sugar high-fat diet (HFD) combination&nbsp;with intraperitoneal injection small dose streptozotocin (STZ, 35 mg/kg). Biochemical analysis histopatholgical examinations were conducted evaluate&nbsp;the anti-diabetic potential water extracts <em>V. baillonii</em>&nbsp;(WVBF). results&nbsp;showed&nbsp;that WVBF treatment can improve&nbsp;hyperglycemia&nbsp;and insulin resistance, ameliorate&nbsp;the&nbsp;liver, kidney pancreas&nbsp;injuries via decreasing&nbsp;inflammatory cytokines such IL-6 TNF-α, oxidative damages. Further investigation suggested that modulates transductions IRS1/PI3K/AKT/GLUT4 AMPK&nbsp;pathways. These findings demonstrate potentials&nbsp;of&nbsp;WVBF of&nbsp;T2DM&nbsp;and possible mechanisms&nbsp;for its hepatoprotective activities.