Lactobacillus from fermented bamboo shoots prevents inflammation in DSS-induced colitis mice via modulating gut microbiome and serum metabolites

• DOI: 10.26599/fshw.2022.9250229
• Publication Date: 2023-11-03T02:20:57Z
• Authors: Xiangru Liu; Xiaoling Lu; Hao Nie; Jing Yan; Zhiwen Ma; Hailin Li; Shixin Tang; Qi Yin; Jingfu Qiu
• Keywords: Lactobacillus rhamnosus; Akkermansia; Lactobacillus casei

Fermented bamboo shoots (FBS) is a region-specific food widely consumed in southwestern China, with&nbsp;<em>Lactobacillus&nbsp;</em>as the predominant fermenting bacteria. However, probiotic potential of&nbsp;<em>Lactobacillus&nbsp;</em>derived from FBS reminds largely unexplored, especially for diseases with low prevalence areas consuming FBS, namely, inflammatory bowel disease.&nbsp;In this study,&nbsp;<em>Lactobacillus pentosus&nbsp;</em>YQ001 and&nbsp;<em>Lactobacillus senioris&nbsp;</em>YQ005 were screening by&nbsp;<em>in vitro&nbsp;</em>probiotic tests to further investigate probiotic-like bioactivity investigation DSS-induced ulcerative colitis mouse.&nbsp;They exhibited more positive effects than&nbsp;<em>Lactobacillus rhamnosus&nbsp;</em>GG preventing intestinal response. The results revealed that both strains improved abundance of deficient microbiota UC mice, including&nbsp;<em>Muribaculaceae&nbsp;</em>and&nbsp;<em>Akkermansia</em>. In serum metabolome, they modulated DSS-disturbed levels metabolites, significant increment cinnamic acid. Meanwhile, reduced expression IL-1β, IL-6 factors and increased ZO-1, Occludin, athelicidin-related antimicrobial peptide (CRAMP) colon. Consequently, these demonstrated that&nbsp;<em>Lactobacillus spp.&nbsp;</em>isolates derived showed promising activity based on gut microbiome homeostasis modulation, anti-inflammation barrier protection mice