Mechanistic Insights into Ginger’s Role in Improving Sperm Malformation Under Heat Stress Using Network Pharmacology and Molecular Docking

• DOI: 10.26689/jcnr.v8i12.9275
• Publication Date: 2025-01-03T04:05:51Z
• Authors: Rongrui Xiao; Huaqin Li; Zheng Huang; Fang Yang; Lijuan Zhao
• Keywords: Docking (animal)

Objective: This study investigates the effects of ginger on sperm dysmorphosis under heat stress using network pharmacology and molecular docking techniques. Methods: The core components, target sites, primary pathways were predicted TCMSP database. Genes associated with malformation identified through databases such as GeneCards DisGeNET, followed by KEGG GO analyses based intersections targets. Core genes via Cytoscape software subjected to ginger’s active components. Results: principal components include β-sitosterol dihydrocapsaicin. Network analysis suggested that exerts its prostate cancer signaling pathway, estrogen inflammatory pathways, nuclear receptor signal transduction. These may ameliorate symptoms caused stress. Conclusion: Integrating findings from docking, potentially modulate expression shock proteins during oxidative pathways. modulation protect spermatogenesis improve malformation.