Heat Shock Proteins and the Maintenance of Gut Barrier Following Burn Injury

• DOI: 10.26859/jnnsci.v2i01.9600
• Publication Date: 2017-10-02T08:14:32Z
• Authors: Abigail R. Cannon; Michael J. Javorski; Mashkoor A. Choudhry
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Traumatic injury, specifically burn remains a prominent medical problem due to the prevalence of secondary, burn-induced complications sepsis and multiple organ dysfunction syndrome. These arise as result gut barrier breakdown following injury. As harbors trillions resident bacteria, any compromise in integrity would allow for bacteria or bacterial products gain access extraintestinal sites potentiating systemic infections inflammation associated with Both experimental human data provide evidence linking heat shock proteins maintenance under various pathological conditions. This article highlights intestinal pathophysiologies injury while proposing potential cytoprotective role intestine innate immune response