Molecular Characterization of Colorectal Cancers

• DOI: 10.29074/ascls.2022003208
• Publication Date: 2024-10-16T17:00:17Z
• Authors: Sally Lewis; Dale Telgenhoff; Brooke Dubansky

<h3>ABSTRACT</h3> Characterization of the molecular mutations in colorectal cancers has made great progress since initial report by Fearon and Vogelstein describing a series histologic changes that correlate to mutations. Since 1990, numerous mutational pathways have been associated with 1 or more actionable targets leading precise treatments development cancers, including inherited sporadic ones. The accumulation leads acquisition cancer-promoting qualities such as increased cellular proliferation, immune evasion, resistance apoptosis. Mutations tumor suppressor protooncogenes <i>KRAS</i> <i>BRAF</i> an important role prognosis therapeutic selection treatment. Broadening use multigene next-generation sequencing panels patients cancer may allow earlier identification patients, providing treatments.