Novel substituted oxadiazole - piperazine derivatives as potential MAO inhibitors: Design, synthesis, in vitro and in silico studies

• DOI: 10.29228/jrp.99
• Publication Date: 2021-12-17T12:16:50Z
• Authors: Harun USLU; Begüm Nurpelin SA...; Derya OSMANİYE; Kadriye BENKLİ
• Keywords: Piperazine; Oxadiazole

Recent studies have shown that there are many piperazine and oxadiazole derivatives with MAO-A and/or MAO-B inhibitory activity.For this reason in our recent study, a new compound series of oxadiazolepiperazine (4a-e) were designed, synthesized, characterized screened their hMAOs activities.When the silico examined, it was seen pharmacokinetic properties interactions receptor synthesized compounds suitable.Compound 4e, NO2 group on 4-position phenyl ring, found showing significant activity.Compound most effective agent against enzyme IC50 value 0.116 ± 0.004 µM.The newly -piperazine appears to be supported design MAO inhibitors obtain more suitable drugs, diseases such as depression anxiety due MAO-A.