Specific Knockout of Notch-1 in Macrophages Modulate the Progression of Hepatic Insulin Resistance in HFD Fed Mice via Regulating IRE1 -XBP1 Signals

• DOI: 10.29271/jcpsp.2024.05.527
• Publication Date: 2024-05-09T04:35:46Z
• Authors: Weiling Zhou; Shuguang Ren; Yonggang Lu; Yuan Wang; Lei Feng; Qian Gao
• Keywords: Knockout mouse

Objective: To develop an intervention based on Notch-1 signalling pathway blockade by investigating the potential application of neurogenic locus notch homologue protein 1(Notch-1) as a key regulator chronic inflammation and adipogenesis in treatment hepatic insulin resistance (HIR).