Development of cardioprotective effect of chronic continuous hypoxia in rats with induced metabolic syndrome

• DOI: 10.29413/abs.2022-7.5-1.20
• Publication Date: 2022-12-14T11:18:15Z
• Authors: I. A. Derkachev
• Keywords: Hypoxia

Background. It is known that adaptation to chronic continuous hypoxia leads a pronounced cardioprotective effect. The efficiency of acute reduced in metabolic syndrome. However, the effectiveness myocardial infarct size-limiting effect syndrome remains an understudied fact. aim. To study development rats with Materials and methods. was carried out on 43 Wistar rats. Adaptation animals performed during 21 days hypoxic chamber (12 % O2, 0.3 CO 2 ). Metabolic modeled by keeping high-carbohydrate high-fat diet (proteins 16 %, fats carbohydrates 46 (including fructose 17 %), cholesterol 0.125 cholic acid 0.5 %) for 12 weeks replacement drinking water 20% solution. Coronary occlusion-reperfusion vivo. size assessed. Results. found after 38 less than control group. In which were kept we observed obesity, decreased glucose tolerance, increased serum triglycerides level, hypertension. improved carbohydrate metabolism, but did not affect severity other disorders. At same time, Conclusion. eliminated hypoxia.