New strategies for the treatment of infections caused by biofilm-producing Klebsiella pneumoniae

• DOI: 10.29413/abs.2024-9.6.7
• Publication Date: 2025-01-27T16:36:21Z
• Authors: T. V. Fadeeva; A. V. Nevezhina
• Keywords: Klebsiella; Klebsiella infections

Treatment of Klebsiella pneumoniae infections is becoming increasingly challenging due to their multiple resistance current antimicrobials. The ability form biofilms a critical virulence feature K. pneumoniae. Biofilms are complex bacterial communities consisting one or more species embedded in an extracellular matrix proteins, carbohydrates, and DNA. Inhibition killing biofilm-producing strains with antibiotics often requires higher concentrations than those required suppress planktonic bacteria. Dosage increases can vary significantly depending on many factors. Therefore, alternative treatments have been sought recently. In this review, the literature was analyzed gain insight into major factors emphasis role enhancing antimicrobial resistance, highlighting importance mechanism for adaptation. search conducted using electronic information resources PubMed, Google Scholar eLibrary. depth limited from 2000 present, share last 5 years 63 %. keywords used were: pneumoniae, biofilm, factors, infection treatment, combination therapy. concepts difference between pathotypes hypervirulent classical, relationship biofilm formation revealed. composition regulation characterized, some influencing structure briefly described. Some new strategies treatment caused by biofilm-forming also presented. Understanding effect antimicrobials paramount clinical practice increased level spread among infectious agents.