Aging of Acute Deep Vein Thrombosis Measured by Radiolabeled 99mTc-rt-PA

• DOI: 10.2967/jnumed.106.039396
• Publication Date: 2007-05-16T01:10:33Z
• Authors: T. Brighton; J. Janssen; S. P. Butler
• Keywords: Male; Venous Thrombosis; Fibrin; Leg; Time Factors; Technetium; Middle Aged; Recombinant Proteins; Veins; 3. Good health; Plasminogen Activators; 03 medical and health sciences; Mucoproteins; 0302 clinical medicine; Thigh; Recurrence; Acute Disease; Humans; Female; Radiopharmaceuticals; Radionuclide Imaging; Protein Binding; Ultrasonography

In previous studies, (99m)Tc-recombinant tissue plasminogen activator (rt-PA) imaging has had a high sensitivity and specificity for the detection of deep vein thrombosis (DVT). this technique, activation site rt-PA undergoes inactivation but fibrin binding is retained. Uptake (99m)Tc-rt-PA into DVT relies on C-terminal lysine residues fibrin. It postulated that as thrombus ages, fewer sites are available there should be progressive decrease in uptake old thrombi compared with fresh thrombi. The ability to differentiate from would have significant clinical implications objective diagnosis recurrent DVT. Our aim was examine relative acute over first 30 d after diagnosis.Seventy-four patients symptomatic were entered study. Patients underwent ultrasound days 1, 7, 30.Residual detected by ultrasonography 46 (84%) 55 day 7 29 (66%) 44 30. Of persisting 72% (33/46) showed uptake. 30, 0% (0/29) uptake.Uptake absent diagnosis. This finding suggests technique can distinguish thrombus.