In Vivo Visualization of Amyloid Deposits in the Heart with 11C-PIB and PET

• DOI: 10.2967/jnumed.111.102053
• Publication Date: 2012-12-14T01:27:39Z
• Authors: Gunnar Antoni; Mark Lubberink; Sergio Estrada; Jan Axelsson; Kristina Carlson; Lars Lindsjö; Tanja Kero; Bengt Långström; Sven-Olof Granstam; Sara Rosengren; Ola Vedin; Cecilia Wassberg; Gerhard Wikström; Per Westermark; Jens Sörensen
• Keywords: Amyloid (mycology); Cardiac Amyloidosis; Pittsburgh compound B

Cardiac amyloidosis is a differential diagnosis in heart failure and associated with high mortality. There currently no noninvasive imaging test available for specific diagnosis. <i>N-</i>[<i>methyl-</i>¹¹C]2-(4′-methylamino-phenyl)-6-hydroxybenzothiazole (¹¹C-PIB) PET used the evaluation of brain amyloidosis. We evaluated potential use ¹¹C-PIB systemic affecting heart. <b>Methods:</b> Patients (<i>n</i> = 10) diagnosed amyloidosis—including involvement either monoclonal immunoglobulin light-chain (AL) or transthyretin (ATTR) type—and healthy volunteers 5) were investigated PET/CT using to study cardiac amyloid deposits ¹¹C-acetate measure myocardial blood flow impact global regional perfusion on PIB retention. <b>Results:</b> Myocardial uptake was visually evident all patients 15–25 min after injection not seen any volunteer. A significant difference retention between controls found. The data indicate that could be visualized ¹¹C-PIB. No correlation index as measured found level, whereas positive segmental level single patient. <b>Conclusion:</b>¹¹C-PIB method type AL ATTR should further both diagnostic tool treatment follow-up.