18F-FDG PET/CT in Staging Patients with Locally Advanced or Inflammatory Breast Cancer: Comparison to Conventional Staging

• DOI: 10.2967/jnumed.112.106864
• Publication Date: 2012-12-05T14:20:52Z
• Authors: David Groheux; Sylvie Giacchetti; Marc Delord; Elif Hindié; Laetitia Vercellino; Caroline Cuvier; Marie-Elisabeth T...; Pascal Merlet; Christophe Hennequin; Marc Espié
• Keywords: Inflammatory breast cancer

The prognosis of patients with locally advanced breast cancer (LABC) remains poor. We prospectively investigated the impact ¹⁸F-FDG PET/CT at initial staging in this clinical setting and compared performance that conventional distant work-up. <b>Methods:</b> During 60 mo, consecutive LABC (clinical T4 or N2–N3 disease) underwent PET/CT. yield was assessed whole group separately for noninflammatory inflammatory cancer. a approach including bone scanning, chest radiography, dedicated CT abdominopelvic sonography contrast-enhanced CT. <b>Results:</b> 117 (<i>n</i> = 35) 82) were included. confirmed N3 nodal involvement stage IIIC revealed unsuspected nodes (infraclavicular, supraclavicular, internal mammary) 32 additional patients. Distant metastases visualized on 43 (46% carcinoma 33% those LABC). Overall, changed 61 (52%). Unguided imaging detected only 28 classified M1 (65%). outperformed metastases, lymph nodes, liver whereas more sensitive lung metastases. accuracy diagnosing lesions 89.7% planar scanning versus 98.3% 97.4% <b>Conclusion:</b>¹⁸F-FDG had advantage allowing chest, abdomen to be examined single session. Almost all by depicted PET/CT, which also showed lesions.