PET Imaging of Disease Progression and Treatment Effects in the Experimental Autoimmune Encephalomyelitis Rat Model

• DOI: 10.2967/jnumed.114.137216
• Publication Date: 2014-06-10T06:32:09Z
• Authors: Daniele de Paula ...; Maria L.H. Vlaming; Sjef C.V.M. Copray; Frans Tielen; Herma J.A. Anthon...; Jurgen W.A. Sijbesma; Carlos A. Buchpiguel; Rudi A.J.O. Dierckx; José W.A. van der...; Erik F.J. de Vries
• Keywords: Encephalomyelitis

The experimental autoimmune encephalomyelitis model is a of multiple sclerosis that closely mimics the disease characteristics in humans. main hallmarks are neuroinflammation (microglia activation, monocyte invasion, and T-cell infiltration) demyelination. PET imaging may be useful noninvasive technique for monitoring progression drug treatment efficacy vivo.Experimental was induced by myelin-oligodendrocyte glycoprotein immunization female Dark Agouti rats. Experimental rats were imaged at baseline days 6, 11, 15, 19 after to monitor microglia activation ((11)C-PK11195) demyelination ((11)C-MeDAS) during normal with dexamethasone.(11)C-PK11195 detected monocytes brain stem spinal cord progression. uptake (11)C-PK11195 elevated dexamethasone-treated animals had shown mild clinical symptoms resolved time imaging. Demyelination not (11)C-MeDAS PET, probably because small size lesions (average, 0.13 mm).PET can used consequences rat model. more sensitive than detecting inflammatory changes central nervous system.