Resting-State Networks as Simultaneously Measured with Functional MRI and PET

• DOI: 10.2967/jnumed.116.185835
• Publication Date: 2017-03-03T01:25:30Z
• Authors: Alexandre Savio; Sarah Fünger; Masoud Tahmasian; Srinivas Rachakonda; Andrei Manoliu; Christian Sorg; Timo Grimmer; Vince Calhoun; Alexander Drzezga; Valentin Riedl; Igor Yakushev
• Keywords: Male; Brain Mapping; Rest; Middle Aged; Magnetic Resonance Imaging; Multimodal Imaging; Healthy Volunteers; 03 medical and health sciences; 0302 clinical medicine; Fluorodeoxyglucose F18; Positron-Emission Tomography; Humans; Female; Nerve Net

Functional MRI (fMRI) studies reported disruption of resting-state networks (RSNs) in several neuropsychiatric disorders. PET with ¹⁸F-FDG captures neuronal activity that is steady state at a longer time span and less dependent on neurovascular coupling. <b>Methods:</b> In the present study, we aimed to identify RSNs data compare their spatial pattern those obtained from simultaneously acquired fMRI 22 middle-aged healthy subjects. <b>Results:</b> Thirteen 17 meaningful could be identified data, respectively. Spatial overlap was fair moderate for default mode, left central executive, primary secondary visual, sensorimotor, cerebellar, auditory networks. Despite recording different aspects neural activity, similar were detected by both imaging modalities. <b>Conclusion:</b> The results argue common substrate encourage testing clinical utility connectivity data.