Improved Detection of Transosseous Meningiomas Using 68Ga-DOTATATE PET/CT Compared with Contrast-Enhanced MRI

• DOI: 10.2967/jnumed.117.191932
• Publication Date: 2017-04-28T01:00:29Z
• Authors: Wolfgang G. Kunz; Lisa M. Jungblut; Philipp M. Kazmie...; Franziska J. Vett...; Andreas Bollenbacher; Jörg C. Tonn; Christian Schichor; Axel Rominger; Nathalie L. Albert; Peter Bartenstein; Maximilian F. Reiser; Clemens C. Cyran
• Keywords: McNemar's test

68Ga-DOTATATE PET/CT enables detection of meningioma tissue based on somatostatin receptor 2 expression. Transosseous extension intracranial meningiomas is known to be an important risk factor for tumor recurrence and patient mortality. We analyzed the diagnostic performance contrast-enhanced MRI (CE-MRI) osseous infiltration using qualitative quantitative imaging parameters. Methods: In this institutional review board-approved retrospective study, subjects were selected from 327 consecutive examinations evaluation confirmed or suspected meningioma. Inclusion criteria CE-MRI within 30 d pathology-confirmed diagnosis with inclusion exclusion transosseous as standard reference. Imaging was by two readers. Tracer uptake values volumes determined. χ2, Mann-Whitney U, Wilcoxon signed rank, McNemar tests, well receiver-operating-characteristic analyses, performed compare variables performance. Results: Eighty-two patients fulfilled criteria. Patients (n = 67) showed significantly larger lesions (median, 12.8 vs. 3.3 mL; P < 0.001) higher tracer (median SUVmax, 14.2 7.6; 0.011) than extraosseous 15). in comparison at a sensitivity (98.5% 53.7%) while maintaining high specificity (86.7% 93.3%) involvement (P 0.001). analysis, assessment better (area under curve, 0.932 0.773). PET/CT- CE-MRI-based volume estimation yielded comparable results 0.132) part 0.636), whereas intraosseous assessed Conclusion:68Ga-DOTATATE improved compared CE-MRI.