Longitudinal Tau PET Using18F-Flortaucipir: The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters

• DOI: 10.2967/jnumed.122.263926
• Publication Date: 2022-10-20T18:05:46Z
• Authors: Denise Visser; Hayel Tuncel; Rik Ossenkoppele; Maqsood Yaqub; Emma E. Wolters; Tessa Timmers; Emma Weltings; Emma M. Coomans; Marijke E. den Ho...; Wiesje M. van der...; Bart N.M. van Ber...; Sandeep S.V. Golla
• Keywords: Binding potential; Standardized uptake value

Semiquantitative PET measures such as SUV ratio (SUVr) have several advantages over quantitative measures, practical applicability and relative computational simplicity. However, SUVr may potentially be affected by changes in blood flow, whereas nondisplaceable binding potential (BP_ND) are not. For ¹⁸F-flortaucipir PET, the sensitivity of for flow is currently unknown. Therefore, we compared semiquantitative parameters longitudinal scans assessed their vulnerability to flow. <b>Methods:</b> Subjects with subjective cognitive decline (<i>n</i> = 38) Alzheimer disease patients 24) underwent baseline 2-y follow-up dynamic scans. BP_ND tracer delivery were estimated using receptor parametric mapping, at 80–100 min was calculated. Regional SUVrs corresponding distribution volume (BP_ND + 1) paired <i>t</i> tests. Additionally, simulations performed model effects larger different categories. <b>Results:</b> Results showed only minor differences between time. Relative small all groups. Simulations illustrated a variable bias depending on amount binding. <b>Conclusion:</b> provided an accurate estimate specific during which small. Notwithstanding, that large(r) affect SUVr. Given it unknown what order magnitude pharmacotherapeutic interventions induce cerebral caution warranted when large(r), clinical trials.