Treatment Landscape of Prostate Cancer in the Era of PSMA Radiopharmaceutical Therapy

• DOI: 10.2967/jnumed.124.267730
• Publication Date: 2025-02-27T16:15:15Z
• Authors: Fabio Turco; Silke Gillessen; Ken Herrmann; Gaetano Paone; Aurelius Omlin

The treatment landscape of prostate cancer is quite complex because the many therapeutic options available in different disease settings (hormonal treatments, chemotherapy, poly(adenosine diphosphate ribose) polymerase inhibitors, radiopharmaceutical therapy). Since most cases we do not have comparative studies between these agents, best sequence patients with remains unsolved. In this review, describe systemic each setting from localized to metastatic castration-resistant disease. We also indicate when use on basis results studies. A special focus review place prostate-specific membrane antigen therapy algorithms.