Cutaneous Manifestations in a Patient with Werner Syndrome -Case Report and Literature Review-

• DOI: 10.29784/ds.200203.0005
• Publication Date: 2002-03-01
• Authors: Yi‐Ju Chen; Chih‐Chao Yang; Chia‐Yu Chu; Yang-Shia Dai; Chee‐Ching Sun
• Keywords: Werner syndrome; Progeria; Premature aging; Genetic disorder

Werner syndrome is a rare autosomal recessive disorder that manifests as genetic instability well early onset of aging-related diseases. Patients with develop aged appearance and graying hair at young age. Other characteristic features include bilateral congenital cataracts, sclerodermoid skin changes, short stature, diabetes mellitus, hypogonadism, osteoporosis, atherosclerosis various types cancer, there are also florid cutaneous manifestations in WS. We herein report the histopathologic findings 25-year-old female syndrome. This first known reported case Taiwan.