Unveiling the effects of nanoparticles-based antiepileptic drugs: Systematic review of in vivo studies

• DOI: 10.30574/gscbps.2024.26.3.0099
• Publication Date: 2024-03-28T02:03:56Z
• Authors: Husnul Khotimah; Fathina Zahrani ...; Fatimah Az Zahra; Rabjhany Anaqah; Shahdevi Nandar ...; Masruroh Rahayu; Hikmawan Wahyu S...
• Keywords: Antiepileptic drug

Background: Resistance and side effects of antiepileptic drugs (AEDs) pose a challenge in epilepsy therapy due to the limited drug bioavailability penetrating Blood-Brain Barrier (BBB). Nanoparticles can be one solution by encapsulating AEDs enhance distribution target cells. This study systematically assesses 1) characteristics nanoparticles, 2) potential nanoparticle managing seizures experimental animal models. Methods: systematic literature review is studies published between 2013 July 2023 PubMed, ScienceDirect, ProQuest, MEDLINE, Scopus databases. Inclusion criteria encompass involving models epilepsy, that exploring nanoparticle-based AEDs. These compare nanoparticles their efficacy with non-nanoparticle groups. Review articles, publications non-English languages, ongoing without results are excluded. Result Discussion: Fourteen met inclusion for this research. All utilized (n = 14). Lipid have more compact size than any other nanoparticle, while combination preparation method has an optimal formation both lipid polymeric nanoparticles. In model indicated were beneficial reducing seizure scores, improving onset latency, providing neuroprotective effects. Conclusion: The delivery varied, influenced formulation factors methods. Nanoparticle-based exhibit higher compared conventional included present opportunity development therapies, although future needed confirm these findings.