A rare case malignant granular cell tumor of the thigh with radiological imaging likely rhabdomyosarcoma: A case report

• DOI: 10.30574/gscbps.2024.27.1.0139
• Publication Date: 2024-04-28T05:50:39Z
• Authors: Eviana Norahmawati; Amelinda Natania...; Satria Pandu Per...; Istan Irmansyah ...; Irma Darinafitri
• Keywords: Granular cell tumors; Thigh; Neural tumor; Malignant soft tissue tumor

Granular cell tumors (GCTs) are uncommon soft tissue characterized by the cytoplasmic granular appearance of neoplastic cells. Malignant GCTs rare neural tumors, intensely aggressive. Both occurrence malignant and its similarities in features with their benign lesions make diagnosis this malignancy difficult. comprise less than 2% mostly found subcutaneous tissues lower extremities, especially thighs. This article presents a case large left thigh 46-year-old woman. Plain radiograph demonstrated mass without bone involvement. MRI images showed solid 7.8 x 5.2 21.6 cm, ill-defined border, irregular edges, suspected rhabdomyosarcoma. Incisional biopsy lesion revealed mixed epithelioid spindle GCTs. Histological examination performed musculoskeletal pathologist, nests sheets to polygonal cells hyperchromatic, eosinophilic cytoplasm, prominent nucleoli, increased mitotic activity, necrosis, areas spindling significant atypia, positive for S100 immunohistochemistry. In conclusion, patient tumor which need be considered diagnosed as stresses importance thorough histological