Mechanisms of Drug Resistance in Breast Cancer

• DOI: 10.30574/gscbps.2024.27.3.0227
• Publication Date: 2024-06-19T04:00:09Z
• Authors: Gabriela S. Urib...; Estefania Galavi...; Ilse L. Rios-Vidaca; Brissia Lazalde
• Keywords: Treatment; Cancer Stem Cells; Breast Cancer; Resistance; Drug

Breast cancer is a complex disease resulting from the interaction between genetic and environmental factors, addressing them constitutes one of major challenges in treatment this disease. Resistance to therapies represents significant obstacle achieving effective results breast cancer, multiple therapeutic approaches are available address patients. The majority cases show estrogen receptor (ERα) expression, treatments targeting pathway critical their approach. However, emergence resistance these common problem, leading recurrence relapse. This review provides an overview mechanisms contributing drug resistance, highlighting relevance epigenetic factors as promising targets clinical resistance. Furthermore, it emphasizes importance further research find strategies that can overcome improve outcomes patients suffering cancer.