Role of RET and BRAF genes in thyroid cancer with relevance in gene therapy treatment

• DOI: 10.30574/gscbps.2024.29.2.0445
• Publication Date: 2024-12-03T00:00:41Z
• Authors: Frida Sofia Aviñ...; Rafael Sebastian...; Ximena Lazcano-M...; Susana Jaquelin ...; Juan Pablo Martí...; Brissia Lazalde
• Keywords: Relevance

At present, cancer is a global problem, among all the types that exist, one of those was taken into account for this research thyroid cancer, especially associated with predisposing genes RET rearrangement and BRAF gene mutation, which incite rapid exit papillary carcinoma, from MAPK signaling pathways conformational change by mutation in at position (V600E) (V599E). The aim subsequent study to provide recent information on involved, as well potential impact targeted therapies inhibit these pathways, such selective inhibitors, providing strategy therapy rather than traditional approach thyroidectomy. In addition way its diagnosis means different genetic markers, oncogenic genes, genome sequence generalized findings endocrine-genetic problem. This also explores non-specific associations above-mentioned causes, generating broader knowledge future medical adaptation disease.