Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder

• DOI: 10.30773/pi.2018.05.23
• Publication Date: 2018-09-17T01:30:58Z
• Authors: Eunsoo Moon; Byeong-Moo Choe; Je-Min Park; Young In Chung; Byung Dae Lee; Jae-Hong Park; Young Min Lee; Hee Jeong Jeong; YongJun Cheon; Yoonmi Choi; Jeonghyun Park
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Original Article

Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC) activities frontal, striatal, hippocampus and cerebellum, but also relative PKC activity ratios among brain regions according of rhythm.The protocol was applied eight-week-old twenty male Institute Cancer Research mice. The patterns were collected through motor measured by Mlog system. Depressive manic proneness examined forced swim test quinpirole-induced open field respectively. Enzyme-linked immunosorbent assay employed measure activities.The presented greater than early (p=0.033). had significantly lower frontal other (p=0.041). former frontal/cerebellar ratio (p=0.047) striatal/frontal (p=0.038) hippocampal/frontal (p=0.007) latter.These findings support potential mechanism bipolar animal model could be an alteration mood regulation related regions. It is required investigate downstream signaling pattern.