Molecular Mechanisms Underlying Drug Resistance of the MCF7/ADR Breast Cancer Cell Line

• DOI: 10.3103/s0027131418050036
• Publication Date: 2018-11-24T07:58:54Z
• Authors: T. A. Bogush; S. A. Kalyuzhny; M. R. Chetyrkina; M. A. Yastrebova; A. M. Scherbakov; O. M. Ryabinina; I. A. Mamichev; E. A. Bogush; A. A. Kamensky
• Keywords: Cancer cell lines

Drug-sensitive MCF7 cells and drug-resistant MCF7/ADR cells are shown to differ with regard to the vimentin and P-gp expression levels, which is indicative of the coexistence of two drug resistance mechanisms in MCF7/ADR cells. The mesenchymal phenotype of epithelial cells makes a much greater contribution to the resistance mechanisms than the ABC transporter’s overexpression, since the difference in the vimentin expression levels in drug-sensitive and drug-resistant cultures is significantly higher than the difference in the P-gp expression.