Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage

• DOI: 10.3109/01480545.2015.1130718
• Publication Date: 2016-01-13T09:47:54Z
• Authors: Arístides A. Poch...; María Belén Hapon; Silvana M. Biolatto; María José Madariaga; Graciela A. Jahn; Cintia N. Konjuh
• Keywords: Anogenital distance

The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is used on a wide variety of terrestrial and aquatic broadleaf weeds. 2,4-D has been shown to produce range adverse effects animal human health. aim the current study was evaluate pre- postnatal exposure rat ventral prostate (VP). Pregnant rats were exposed daily oral doses 70 mg/kg/day from 16 days gestation up 23 after delivery. Then, treated groups (n = 8) fed with added diet until sacrificed by decapitation day (PND) 45, 60, or 90. Morphometric studies performed androgen receptor (AR) protein levels in VP determined. AR, insulin-like growth factor-I (IGF-1) (IGF-1R) mRNA expression along testosterone (T), dihydroxytestosterone (DHT), hormone (GH) IGF-1 serum also determined ascertain whether these parameters differentially affected. Results this showed that during adulthood altered development gland male rats, delaying it at early ages while increasing its size adults, indicate could behave as endocrine disruptors (EDs).