Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lungKlebsiella Pneumoniaeinfection

• DOI: 10.3109/01902148.2011.654045
• Publication Date: 2012-03-06T18:17:33Z
• Authors: Faryal Durrani; David S. Phelps; Judith Weisz; Patricia Silveyra; Sanmei Hu; Anatoly N. Mikerov; Joanna Floros
• Keywords: Dihydrotestosterone

Survival of mice after Klebsiella pneumoniae infection and phagocytosis by alveolar macrophages (AMs), in the presence or absence ozone (O3) exposure prior to infection, is sex dependent. The objective this work was study role gonadal hormones, 5α-dihydrotestosterone (DHT) 17β-estradiol (E2), on mouse survival filtered air (FA) O3 exposure. Gonadectomized female (G×F) male (G×M) implanted with control hormone pellets (DHT G×F, E2 G×M), exposed (2 ppm, 3h) FA, infected K. were monitored for survival. G×F identical FA exposure; G×M resulted lower compared FA. In O3-exposed females, gonadectomy increased intact females G×M+E2. A similar effect observed G×F+DHT. combined negative oxidative stress higher E2. Gonadectomy eliminated (females) minimized (males) previously differences response stress, treatment restored them. These findings indicate that hormones and/or have a significant