Endocan, a novel marker of endothelial dysfunction in patients with essential hypertension: Comparative effects of amlodipine and valsartan

• DOI: 10.3109/08037051.2014.972816
• Publication Date: 2014-11-12T16:47:18Z
• Authors: Turgay Celık; Sevket Balta; Murat Karaman; Seyıt Ahmet Ay; Saıt Demırkol; Cengız Ozturk; Mustafa Dınc; Hılmı U. Unal; M. Ilker Yılmaz; Selım Kılıc; Gulcan Kurt; A. Tas; Atıla Iyısoy; Fosca Quartı-Trevano; Francesco Fıcı; Guıdo Grassı
• Keywords: Amlodipine; Endothelial Dysfunction; Essential hypertension

Vascular inflammation plays an important role in the pathophysiology of hypertension and high levels endocan may reflect ongoing vascular hypertensive patients. In present hypothesis-generating study, we aimed at investigating comparative effects amlodipine valsartan on newly diagnosed The study population consisted 37 untreated patients who were randomized to two treatment arms. After baseline assessment, each patient was randomly allocated either 10 mg daily (n = 18, 7 males) or 160 19, 3 treated for a 3-month period. Sphygmomanometric blood pressure (BP) serum measured before every 2 weeks during drug treatment. There no statistically significant difference between arms as far socio-demographic clinical characteristics are concerned. period, systolic diastolic BP values significantly reduced by antihypertensive (p < 0.001). Furthermore, decreased both 0.05). However, caused greater percent decrease circulating compared with end Both drugs sensitivity C-reactive protein values. statistical vs achieved only group amlodipine. No correlation found plasma reduction. results this suggest that effects, which more evident amlodipine, contribute anti-inflammatory exerted target.