Ion- and pH-activated novelin-situgel system for sustained ocular drug delivery

• DOI: 10.3109/10611860903508788
• Publication Date: 2010-01-08T07:24:15Z
• Authors: Himanshu Gupta; T. Velpandian; Sanyog Jain
• Keywords: Gellan gum; Artificial tears; Eye drop; Guar gum

Poor bioavailability (<1%) of drugs from conventional eye drops is mainly due to the various precorneal loss factors which include rapid tear turnover, systemic drug absorption through naso-lachrymal duct, transient residence time solution in cul-de-sac and relative impermeability corneal epithelial membrane. The present study describes formulation evaluation chitosan gellan gum based novel in-situ gel system activated by dual physiological mechanisms. Chitosan (a pH-sensitive polymer) combination with (an ion-activated were used as gelling agent. Timolol maleate, frequently for glaucoma therapy was model check efficacy formulation. developed characterized vitro parameters, example, clarity, gelation pH, isotonicity, sterility, viscosity, transcorneal permeation profile, ocular irritation. Ocular retention studied gamma scintigraphy a significant increase observed. also found be nonirritant well tolerable. can viable alternative treatment diseases suitable clinical application.