Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: design, methods and initial findings of the Germina cohort study

• DOI: 10.31219/osf.io/ed4fb
• Publication Date: 2024-05-09T14:09:47Z
• Authors: Daniel Fatori; Elizabeth Shephard; Nathalia Ferrazzo...; GROVER ENRIQUE CA...; Jaqueline Yu Ting...; Pedro Tótolo; Anthonieta Looman...; Caio Isaias; Davi Pereira dos ...; Fabiele Baldino R...; Gerson Shigeru Ko...; Adriana Argeu; monike.nteixeira...; ANA CLAUDIA MATTI...; Maria Teresa Bech...; Danila Cristina P...; Helena Paula Bren...; Marília Scliar; Paulo A. Schüroff; Pedro Zuccolo; Rogério Lerner; Stephania Geraldini; Veronica Luiza Va...; Alicia Matijasevich; Alline Campos; Andre Fujita; Andre Carlos Ponc...; Carla R. Taddei; MARIA RITA DOS SA...; Patricia C. B. Be...; Guilherme Polanczyk
• Keywords: Medical Sciences; Medicine and Health Sciences

This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers trajectories executive functions language development in first 3 years life. 557 mother-infant dyads (mean age mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline are currently collecting data for other timepoints. A linear regression was used predict Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework 15 domains. Significant associations were found between socioeconomic/demographic characteristics (B=0.29), epigenetics (B=0.11), EEG theta (B=0.14) beta activity microbiome functional pathways (B=0.08) domains, infant development, suggesting potential interventions prevent impairments.